Batch and continuous sterilization pdf

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Related Books Free with a 30 day trial from Scribd. Dry: A Memoir Augusten Burroughs. Related Audiobooks Free with a 30 day trial from Scribd. Empath Up! In order to sterilize a batch, calculate the total area underneath the curve. Therefore, model death using first order kinetics and integrate as seen above. This will yield a temperature and the corresponding duration of time needed to sterilize the media. Advantages: Most widely used technique Simple operation No additional materials are added to the media itself Disadvantages: More expensive heat requirements than continuous sterilization Best results occur in well-mixed closed vessels 5.

Continuous Sterilization 6. The medium stays in this loop for a predetermined holding time until the entire medium is sterile. Advantages: Uniform steam requirements throughout the duration of the sterilization Simplified process control Shorter sterilization time means less thermal degradation of medium Disadvantages: High demand for steam in a shorter period of time than batch Concentration of media becomes dilute due to steam condensation Since steam is actually dispersed in media, steam must be clean to avoid contamination 8.

Advantages of Continuous Sterilization process over Batch Sterilization 9. Both the heat and the cooling water are spent with no opportunity for energy recovery. This makes scale-up very simple. That pleases us. Continuous Sterilization. Highlights Swift and efficient large-scale media sterilization Independent sterilization of equipment and medium Steady-state conditions. A control system ensures that the sterilizing temperature has been reached before the medium is pumped into the reactor or is returned to the media vessel.

The system is very compact with a base size of 65 x 65 cm; it is also very efficient with its pipe-in-pipe heat exchangers, insulated holding section and a three-stage flow rate control. Swirl-flow heat exchangers, insulated thermal soaking zones, control and automation systems as well as CIP systems are designed to ensure high flow rates, excellent heat transfer, swift and thorough cleanability and maximum safety in the aseptic process.

Recuperators are used for efficient energy recovery and for cutting costs. Applications Full sterilization of production reactors are time and energy consuming. In addition to this, sensitive media can denature during long heating and sterilization phases, which negatively affects the process.